Tag Archives: stem cells

Have a heart? Don’t let it break. Now they can recycle it!

I came on an intriguing article in MIT Technology Review, “Transplant surgeons revive hearts after death.”

These days, we’re familiar with heart transplants from brain-dead patients into others needing a new, healthy heart.

But in a new experimental breakthrough, successes have been achieved in transplanting the hearts of those not brain dead. Yes, there are procedural and ethical issues involved.

Mind you, this involves actual human hearts, not 3-D printed replacements, or bits of heart tissue grown in labs from human stem cells.

But the possibility raises some issues of medical ethics to be explored: if the donor is not brain dead, when and by what criteria can the heart be removed?

Rather than dig in deeply here, I’ll refer you to the article itself. You’ll see a “reanimated” donated heart actually beating outside the bodies of both donor and recipient.  Here’s the link.

Organ harvesting from aborted human fetuses, medical ethics, and the medical techno-thriller, A REMEDY FOR DEATH

The  method used in my medical techno-thriller, A REMEDY FOR DEATH, depends on human stem cells from adult donors (Induced Pluripotent Cells—IPS cells) rather than tissue from aborted fetuses–a topic very much in the news recently because of a series of videos.

(Want to know more  about Induced Pluripotent Cells? Here’s a link to a basic Wikipedia overview.)

In case the link doesn’t work, here it is in open form:   https://en.wikipedia.org/wiki/Induced_pluripotent_stem_cell

 That said, an alternate research strand is very much in the news these days—fetal tissue research using organs from aborted fetuses.

Reasonable people can—and most definitely do, strongly—disagree on the medical ethics not only of abortion but also of “organ harvesting” from the resulting fetus. The fields of bio-engineering, tissue engineering and regenerative medicine are moving very fast, and  medical ethicists are struggling to keep apace.

I expect you’ve heard about—and perhaps watched—the series of videos made by the Center for Medical Progress, an anti-abortion group recording interviews with Planned Parenthood staffers, as well as shots of the product of abortions induced in Planned Parenthood  facilities.

In A REMEDY FOR DEATH,   I  raised different but related issues involving bio-engineering, organ harvesting and other issues–different because the plot-line does not involve aborted fetuses. But it does  touch upon some of the same issues of medical ethics and biological research ethics as are raised by these videos and resulting discussions.

For  an informative, balanced article on this issue of using aborted human fetal tissue in research, I suggest Sarah Kliff’s piece in VOX: “The Planned Parenthood controversy over aborted fetus body parts, explained”

That link repeated, in case it didn’t come through:  http://www.vox.com/2015/7/14/8964513/planned-parenthood-aborted-fetuses

A REMEDY FOR DEATH . . . Scientists grow full-sized beating human hearts from stem cells

My bio-science techno-thriller, A REMEDY FOR DEATH, focuses on a group of super-rich trying to re-create themselves in “healthy, horny 21-year-old bodies with all our accumulated savvy from this lifetime”.
Seems far out?
Not so, as hardly a week goes by without elements of just-that being announced by science labs around the world.
Articles report in the online London Independent https://www.indy100.com/article/human-heart-grow-stem-cells-science-transplant-medicine-technology-7521166 and  by Alexandra Ossola in Popular Science  http://www.popsci.com/scientists-grow-transplantable-hearts-with-stem-cells   how not only is this a step toward the scheme of the bad-guys in A REMEDY FOR DEATH, but — better for the world– will ultimately produce many more of the replacement hearts needed by those waiting for heart transplants.

The photo here comes from the article in the professional journal Circulation Research, where you can read more  http://circres.ahajournals.org/content/118/1/56